The principal cytochrome P450 isoenzyme associated appears for being CYP2E1, with CYP1A2 and CYP3A4 as further pathways. Approximately 85% of an oral dose appears within the urine in 24 hrs of administration, most as the glucuronide conjugate, with little amounts of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity info.The risk of